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Molecular Genetics on Extraversion - Dictionary of Arguments

Corr I 294
Extraversion/motivation/molecular genetics/Munafò: The dopaminergic system is involved in appetitive and motivational behaviours (Comings and Blum 2000)(1), and pharmacological challenge studies indicate a relationship between dopaminergic hyperactivity and reward-seeking, as well as motivational factors associated with both Extraversion and novelty-seeking (Netter 2006)(2), suggesting that these traits may share a common neurobiological basis.
The dopamine D4 receptor (DRD4) gene is highly polymorphic, although research evaluating behavioural and psychiatric phenotypes has focused largely on a variable number of tandem repeats (VNTR) polymorphism in exon III, and in particular the presence or absence of the seven-repeat (‘long’) allele. See (Asghari, Schoots, Van Kats et al. 1994)(3), (Asghari, Sanyal, Buchwaldt et al. 1995)(4),(Ekelund, Suhonen, Jarvelin et al. 2001(5); Strobel et al. 2002)(6), (Okuyama, Ishiguro, Toru and Arinami 1999(7); Ronai, Barta, Guttman et al. 2001)(8).



1. Comings, D. E. and Blum, K. 2000. Reward deficiency syndrome: genetic aspects of behavioural disorders, Progress in Brain Research 126: 325–41
2. Netter, P. 2006. Dopamine challenge tests as an indicator of psychological traits, Human Psychopharmacology 21: 91–9
3 .Asghari, V., Schoots, O., Van Kats, S., Ohara, K., Jovanovic, V., Guan, H. C. et al. 1994. Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes, Molecular Pharmacology 46: 364–73
4. Asghari, V., Sanyal, S., Buchwaldt, S., Paterson, A., Jovanovic, V. and Van Tol, H. H. 1995. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants, Journal of Neurochemistry 65: 1157–65
5. Ekelund, J., Suhonen, J., Jarvelin, M. R., Peltonen, L., Lichtermann, D. 2001. No association of the -521 C/T polymorphism in the promoter of DRD4 with novelty seeking, Molecular Psychiatry 6: 618–19
6. Strobel, A., Lesch, K. P., Hohenberger, K., Jatzke, S., Gutzeit, H. O., Anacker, K., Brocke, B. 2002. No association between dopamine D4 receptor gene exon III and -521C/T polymorphism and novelty seeking, Molecular Psychiatry 7: 537–8
7. Okuyama, Y., Ishiguro, H., Toru, M. and Arinami, T. 1999. A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia, Biochemical and Biophysical Research Communications 258: 292–5
8. Ronai, Z., Barta, C., Guttman, A., Lakatos, K., Gervai, J., Staub, M. and Sasvari-Szekely, M. 2001. Genotyping the -521C/T functional polymorphism in the promoter region of dopamine D4 receptor (DRD4) gene, Electrophoresis 22: 1102–5



Marcus R. Munafò,“Behavioural genetics: from variance to DNA“, in: Corr, Ph. J. & Matthews, G. (eds.)2009. The Cambridge handbook of Personality Psychology. New York: Cambridge University Press


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Explanation of symbols: Roman numerals indicate the source, arabic numerals indicate the page number. The corresponding books are indicated on the right hand side. ((s)…): Comment by the sender of the contribution. Translations: Dictionary of Arguments
The note [Author1]Vs[Author2] or [Author]Vs[term] is an addition from the Dictionary of Arguments. If a German edition is specified, the page numbers refer to this edition.
Molecular Genetics
Corr I
Philip J. Corr
Gerald Matthews
The Cambridge Handbook of Personality Psychology New York 2009

Corr II
Philip J. Corr (Ed.)
Personality and Individual Differences - Revisiting the classical studies Singapore, Washington DC, Melbourne 2018


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Ed. Martin Schulz, access date 2021-06-18
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